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Frontiers - Endocrine Disrupting Chemicals: An Occult Mediator of Metabolic Disease - Endocrinology Frontiers - Endocrine Disrupting Chemicals: An Occult Mediator of Metabolic Disease - Endocrinology
Endocrine disrupting chemicals (EDCs), a heterogeneous group of exogenous chemicals that can interfere with any aspect of endogenous hormones, represent an emerging global threat for human metabolism. There is now considerable evidence that the observed upsurge of metabolic disease cannot be fully attributed to increased caloric intake, physical inactivity, sleep deficit, and ageing. Among environmental factors implicated in the global deterioration of metabolic health, EDCs have drawn the biggest attention of scientific community, and not unjustifiably. EDCs unleash a coordinated attack toward multiple components of human metabolism, including crucial, metabolically-active organs such as hypothalamus, adipose tissue, pancreatic beta cells, skeletal muscle, and liver. Specifically, EDCs' impact during critical developmental windows can promote the disruption of individual or multiple systems involved in metabolism, via inducing epigenetic changes that can permanently alter the epigenome in the germline, enabling changes to be transmitted to the subsequent generations. The clear effect of this multifaceted attack is the manifestation of metabolic disease, clinically expressed as obesity, metabolic syndrome, diabetes mellitus, and non-alcoholic fatty liver disease. Although limitations of EDCs research do exist, there is no doubt that EDCs constitute a crucial parameter of the global deterioration of metabolic health we currently encounter. Endocrine disrupting chemicals (EDCs), a heterogeneous group of exogenous chemicals that can interfere with any aspect of endogenous hormones, represent an emerging global threat for human metabolism. There is now considerable evidence that the observed upsurge of metabolic disease cannot be fully attributed to increased caloric intake, physical inactivity, sleep deficit and ageing. Among environmental factors implicated in the global deterioration of metabolic health, EDCs have drawn the biggest attention of scientific community, and not unjustifiably. EDCs unleash a coordinated attack towards multiple components of human metabolism, including crucial, metabolically-active organs such as hypothalamus, adipose tissue, pancreatic beta cells, skeletal muscle and liver. Specifically, EDCs’ impact during critical developmental windows can promote the disruption of individual or multiple systems involved in metabolism, via inducing epigenetic changes that can permanently alter the epigenome in the germline, enabling changes to be transmitted to the subsequent generations. The clear effect of this multifaceted attack is the manifestation of metabolic disease, clinically expressed as obesity, metabolic syndrome, diabetes mellitus and non-alcoholic fatty liver disease. Although limitations of EDCs research do exist, there is no doubt that EDCs constitute a crucial parameter of the global deterioration of metabolic health we currently encounter.
https://www.frontiersin.org/
Annual report 2018 Annual report 2018
Annual report of the Galenica Group and Galenica Ltd.
https://www.galenica.com/
Standorte Galexis AG - www.galexis-aerzteservice.ch Standorte Galexis AG - www.galexis-aerzteservice.ch
Suchen Sie einen Standort oder eine Adresse? Unsere Karte bietet Ihnen einen vollständigen Überblick.
https://www.galexis-aerzteservice.ch/
Garden Grove Hospital Medical Center - Prime Healthcare Services,Southern California Garden Grove Hospital Medical Center - Prime Healthcare Services,Southern California
For compassionate and professional care from a medical center recognized as one of the top 100 Hospitals in the Nation, turn to the medical professionals at Garden Grove Hospital Medical Center.
https://www.gardengrovehospital.com/
Project Category: Irrigation - GenPro Energy Solutions Project Category: Irrigation - GenPro Energy Solutions
Project Category: Irrigation
https://www.genproenergy.com/
Mitglieder Mitglieder
Mitglieder
https://www.gewerbeverein-schenkenbergertal.ch/
Torgorme irrigation project to create 12,000 jobs Torgorme irrigation project to create 12,000 jobs
2018-07-14 - The $34 million Kpong Left Bank Irrigation Project (KLBIP) at Torgorme in the North Tongu District of the Volta Region is estimated to create a minimum of 12,000 direct jobs yearly when completed.
https://www.ghanaweb.com/
Pima-Maricopa Irrigation Project Pima-Maricopa Irrigation Project
Pima-Maricopa Irrigation Project
https://www.gilariver.com/
Healthcare & Hospital Construction Solutions - Gilbane Building Company Healthcare & Hospital Construction Solutions - Gilbane Building Company
Learn more about how we help healthcare clients improve facilities by providing building solutions for the unique challenges of healthcare construction.
https://www.gilbaneco.com/
Ethiopia Ethiopia
Ethiopia is one of the world’s fastest-growing economies, but prevailing social attitudes exclude girls almost entirely from these economic opportunities.
https://www.girleffect.org/

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